00:00:00 / 00:00:00
3 7

Antibiotic resistance is a serious public health concern. Responding to this problem effectively requires characterising the factors (i.e. evolutionary and ecological processes) that determine resistance frequencies. At present, we do not have ecologically plausible models of resistance that are able to replicate observed trends - we are therefore unable to make credible predictions about resistance dynamics. In this talk, I will present work motivated by three tends observed in Streptococcus pneumoniae resistance data: the stable coexistence of antibiotic sensitivity and resistance, variation between resistance frequencies between pneumococcal lineages and correlation in resistance to different antibiotics. I will propose that variation in the fitness benefit gained from resistance arising from variation in the duration of carriage of pneumococcal lineages is a parsimonious explanation for all three trends. This eco-evolutionary framework could allow more accurate prediction of future resistance levels and play a role in informing strategies to prevent the spread of resistance.

Informations sur la vidéo

Données de citation

  • DOI 10.24350/CIRM.V.19612603
  • Citer cette vidéo Lehtinen Sonja (17/02/2020). Evolutionary ecology of antibiotic resistance. CIRM. Audiovisual resource. DOI: 10.24350/CIRM.V.19612603
  • URL https://dx.doi.org/10.24350/CIRM.V.19612603


  • COLIJN, Caroline, COHEN, Ted, FRASER, Christophe, et al. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?. Journal of The Royal Society Interface, 2010, vol. 7, no 47, p. 905-919. - https://doi.org/10.1098/rsif.2009.0400
  • LEHTINEN, Sonja, BLANQUART, François, CROUCHER, Nicholas J., et al. Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage. Proceedings of the National Academy of Sciences, 2017, vol. 114, no 5, p. 1075-1080. - https://doi.org/10.1073/pnas.1617849114
  • LEES, John A., CROUCHER, Nicholas J., GOLDBLATT, David, et al. Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration. Elife, 2017, vol. 6, p. e26255. - https://doi.org/10.7554/eLife.26255
  • KOUYOS, Roger, KLEIN, Eili, et GRENFELL, Bryan. Hospital-community interactions foster coexistence between methicillin-resistant strains of Staphylococcus aureus. PLoS pathogens, 2013, vol. 9, no 2. - https://dx.doi.org/10.1371%2Fjournal.ppat.1003134
  • COBEY, Sarah, BASKERVILLE, Edward B., COLIJN, Caroline, et al. Host population structure and treatment frequency maintain balancing selection on drug resistance. Journal of The Royal Society Interface, 2017, vol. 14, no 133, p. 20170295. - https://doi.org/10.1098/rsif.2017.0295
  • BLANQUART, François, LEHTINEN, Sonja, LIPSITCH, Marc, et al. The evolution of antibiotic resistance in a structured host population. Journal of The Royal Society Interface, 2018, vol. 15, no 143, p. 20180040. - https://doi.org/10.1098/rsif.2018.0040
  • KRIEGER, Madison S., MOREAU, Joshua M., ZHANG, Haiyu, et al. Novel cytokine interactions identified during perturbed hematopoiesis. bioRxiv, 2018, p. 484170. - http://dx.doi.org/10.1101/484170
  • DAVIES, Nicholas G., FLASCHE, Stefan, JIT, Mark, et al. Within-host dynamics shape antibiotic resistance in commensal bacteria. Nature ecology & evolution, 2019, vol. 3, no 3, p. 440-449. - https://doi.org/10.1038/s41559-018-0786-x
  • CHANG, Hsiao-Han, COHEN, Ted, GRAD, Yonatan H., et al. Origin and proliferation of multiple-drug resistance in bacterial pathogens. Microbiol. Mol. Biol. Rev., 2015, vol. 79, no 1, p. 101-116. - https://doi.org/10.1128/MMBR.00039-14
  • LEHTINEN, Sonja, BLANQUART, François, LIPSITCH, Marc, et al. On the evolutionary ecology of multidrug resistance in bacteria. PLoS pathogens, 2019, vol. 15, no 5, p. e1007763. - https://doi.org/10.1371/journal.ppat.1007763
  • HANAGE, William Paul, FRASER, Christophe, TANG, Jing, et al. Hyper-recombination, diversity, and antibiotic resistance in pneumococcus. Science, 2009, vol. 324, no 5933, p. 1454-1457. - http://dx.doi.org/10.1126/science.1171908
  • MOSTOWY, Rafał J., CROUCHER, Nicholas J., DE MAIO, Nicola, et al. Pneumococcal capsule synthesis locus cps as evolutionary hotspot with potential to generate novel serotypes by recombination. Molecular Biology and Evolution, 2017, vol. 34, no 10, p. 2537-2554. - https://doi.org/10.1093/molbev/msx173
  • MOSTOWY, Rafal, CROUCHER, Nicholas J., ANDAM, Cheryl P., et al. Efficient inference of recent and ancestral recombination within bacterial populations. Molecular biology and evolution, 2017, vol. 34, no 5, p. 1167-1182. - https://doi.org/10.1093/molbev/msx066
  • GLADSTONE, Rebecca A., LO, Stephanie W., LEES, John A., et al. International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact. EBioMedicine, 2019, vol. 43, p. 338-346. - https://doi.org/10.1016/j.ebiom.2019.04.021
  • CHAGUZA, Chrispin, ANDAM, Cheryl P., HARRIS, Simon R., et al. Recombination in Streptococcus pneumoniae lineages increase with carriage duration and size of the polysaccharide capsule. MBio, 2016, vol. 7, no 5, p. e01053-16.
  • LEHTINEN, Sonja, CHEWAPREECHA, Claire, LEES, John, et al. Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae. BioRxiv, 2019, p. 656751. - http://dx.doi.org/10.1101/656751

Dernières questions liées sur MathOverflow

Pour poser une question, votre compte Carmin.tv doit être connecté à mathoverflow

Poser une question sur MathOverflow


  • Mettez des vidéos en favori
  • Ajoutez des vidéos à regarder plus tard &
    conservez votre historique de consultation
  • Commentez avec la communauté
  • Recevez des notifications de mise à jour
    de vos sujets favoris
Donner son avis