Thematic Month Week 3: Mathematical Modeling and Statistical Analysis of Infectious Disease Outbreaks / Mois thématique Semaine 3 : Modélisation mathématique et analyses statistique des épidémies de maladies infectieuses

Collection Thematic Month Week 3: Mathematical Modeling and Statistical Analysis of Infectious Disease Outbreaks / Mois thématique Semaine 3 : Modélisation mathématique et analyses statistique des épidémies de maladies infectieuses

Organizer(s) Britton, Tom ; Forien, Raphaël ; Hubert, Florence ; Pardoux, Etienne

Date(s) 17/02/2020 - 21/02/2020

linked URL https://conferences.cirm-math.fr/2303.html

00:00:00 / 00:00:00

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Evolutionary ecology of antibiotic resistance

By Sonja Lehtinen

Antibiotic resistance is a serious public health concern. Responding to this problem effectively requires characterising the factors (i.e. evolutionary and ecological processes) that determine resistance frequencies. At present, we do not have ecologically plausible models of resistance that are able to replicate observed trends - we are therefore unable to make credible predictions about resistance dynamics. In this talk, I will present work motivated by three tends observed in Streptococcus pneumoniae resistance data: the stable coexistence of antibiotic sensitivity and resistance, variation between resistance frequencies between pneumococcal lineages and correlation in resistance to different antibiotics. I will propose that variation in the fitness benefit gained from resistance arising from variation in the duration of carriage of pneumococcal lineages is a parsimonious explanation for all three trends. This eco-evolutionary framework could allow more accurate prediction of future resistance levels and play a role in informing strategies to prevent the spread of resistance.

Information about the video

Date of recording 17/02/2020
Date of publication 03/03/2020
Institution CIRM
Licence CC BY NC ND
Language English
Audience Researchers
Director(s) Guillaume Hennenfent
Format MP4

Citation data

DOI 10.24350/CIRM.V.19612603
Cite this video Lehtinen, Sonja (17/02/2020). Evolutionary ecology of antibiotic resistance. CIRM. Audiovisual resource. DOI: 10.24350/CIRM.V.19612603
URL https://dx.doi.org/10.24350/CIRM.V.19612603

Domain(s)

Bibliography

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LEHTINEN, Sonja, BLANQUART, François, CROUCHER, Nicholas J., et al. Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage. Proceedings of the National Academy of Sciences, 2017, vol. 114, no 5, p. 1075-1080. - https://doi.org/10.1073/pnas.1617849114
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