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Multi-level mathematical models for cell migration in dense fibrous environments

De Luigi Preziosi

Apparaît également dans la collection : Ecoles de recherche

Cell-extracellular matrix interaction and the mechanical properties of cell nucleus have been demonstrated to play a fundamental role in cell movement across fibre networks and micro-channels and then in the spread of cancer metastases. The lectures will be aimed at presenting several mathematical models dealing with such a problem, starting from modelling cell adhesion mechanics to the inclusion of influence of nucleus stiffness in the motion of cells, through continuum mechanics, kinetic models and individual cell-based models.

Informations sur la vidéo

Données de citation

  • DOI 10.24350/CIRM.V.19421703
  • Citer cette vidéo Preziosi, Luigi (18/07/2018). Multi-level mathematical models for cell migration in dense fibrous environments. CIRM. Audiovisual resource. DOI: 10.24350/CIRM.V.19421703
  • URL https://dx.doi.org/10.24350/CIRM.V.19421703

Bibliographie

  • Butcher, D.T., Alliston, T., Weaver, V.M. (2009). A tense situation: forcing tumour progression. Nature Reviews Cancer, 9, 108-122 - http://dx.doi.org/10.1038/nrc2544
  • Guilak, F., Cohen, D.M., Estes, B.T., Gimble, J.M., Liedtke, W., & Chen, C.S. (2009). Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell, 5, 17-26 - https://doi.org/10.1016/j.stem.2009.06.016
  • Ingber, D.E. (2003). Mechanobiology and diseases of mechanotransduction. Annals of medicine, 35(8), 564-577 - https://doi.org/10.1080/07853890310016333
  • Kassa, L., Erler, J.T., Dembo, M., & Weaver, V.M. (2007). Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis. The International Journal of Biochemistry & Cell Biology, 39(11), 1987-1994 - https://doi.org/10.1016/j.biocel.2007.06.025
  • Lindvall, O., & Kokaia, Z. (2010). Stem cells in human neurodegenerative disorders — time for clinical translation? The Journal of Clinical Investigation, 120(1), 29-40 - https://dx.doi.org/10.1172%2FJCI40543
  • Lindvall, O., & Kokaia, Z. (2006). Stem cells for the treatment of neurological disorders. Nature, 441, 1094-1096 - http://dx.doi.org/10.1038/nature04960
  • Sun, Y., Chen, C.S., & Fu, J. (2012). Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annual Review of Biophysics, 41, 519-542 - https://doi.org/10.1146/annurev-biophys-042910-155306
  • Tosin, A., & Preziosi, L. (2010). Multiphase modeling of tumor growth with matrix remodeling and fibrosis. Mathematical and Computer Modelling, 52(7–8), 969-976 - https://doi.org/10.1016/j.mcm.2010.01.015

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