By Jose Munoz
We present a rheological model based on a dynamic adaptation of the rest-length of the tissue during morphogenesis. This adaptation is dependent on previous strain levels by using a delay parameter. We show that the stability of the displacements is dependent on this delay and other material parameters. We demonstrate that, unexpectedly, an increase in frictional viscosity destabilises the oscillatory response. The extension of the model to non-linear strain measures is able to reproduce the observed sustained oscillations in embryonic tissues. The model is applied to the analysis of the Central Nervous System (CNS) in Drosophila fly. Increase in stiffness and a decrease in viscosity allows us to hypothesise a instability of the oscillations prior to CNS condensation. Although other reasons for the triggering of the morphogenetic movements cannot be discarded, the theoretical and experimental measurements point towards a possible source of tissue instabilities during morphogenesis.
By Richard Bailleul
By Florence Hubert
By Pierre-Emmanuel Jabin
By Markus Schmidtchen
By Camille Pouchol
By Monika Joanna Piotrowska
By Annabelle Collin
By Sébastien Benzekry
By Jose Munoz
By Pasquale Ciarletta
By Olivier Saut
By Anna Marciniak-Czochra
By Aleksandra Ardaseva
By Kevin Painter
By Nadia Loy
By Min Tang
By Christian Schmeiser
By Thierry Goudon
By Ariane Trescases
By Monica Colpi
By Albert Schwarz
By Albert Schwarz
By Juan Camilo Arosemena Serrato
By Pieter Spaas
By Francesca Arici
By Amine Marrakchi
