Appears in collection : 2022 - T1 - WS1 - Tissue growth and movement

The lamellipodium is a flat cell protrusion typically adhering to flat substrates, where it acts as cell motility engine. It is supported by a network of filaments of polymerized actin. The FBLM is a two-dimensional continuum model based on the mechanical behavior of this network and its dynamics, including (de)polymerization, cross-linking, substrate adhesion, and other effects. I shall report about recent efforts to reduce this model to the dynamics of an active curve along the cell periphery.