Appears in collection : 2022 - T1 - WS1 - Tissue growth and movement

Electroporation is a complex phenomenon that occurs when biological tissues are subjected to electric pulses. Electroporation makes it possible to either kill directly the cells in the target region (tumor) or to introduce molecules into living cells. However, one of the main limitation of using electroporation in the clinical routine comes from the technical difficulties raised by such therapies, in particular it is difficult to well determine the treated zone. Mathematical models and numerical simulations can be used either to better understand the effects of the electric field on the cells or to compute the distribution of the electric field allowing to provide a numerical evaluation of the treatment. In this context, the available medical data - volume and tumor heterogeneity extracted from experimental/medical imaging or measurements of the electric intensity that flows through needles can be used to identify the model parameters through strategies of data assimilation. The full strategy will be illustrated on various examples.