00:00:00 / 00:00:00

Signaling gradients in surface dynamics as basis for regeneration in flatworms

De Angela Stevens

Apparaît dans la collection : Thematic Month Week 4: Mathematics of Complex Systems in Biology and Medicine / Mois thématique Semaine 4 : Mathématiques des systèmes complexes en biologie et en médecine

We introduce and analyze a mathematical model for the regeneration of planarian flatworms. This system of differential equations incorporates dynamics of head and tail cells which express positional control genes that in turn translate into localized signals that guide stem cell differentiation. Orientation and positional information is encoded in the dynamics of a long range wnt-related signaling gradient. We motivate our model in relation to experimental data and demonstrate how it correctly reproduces cut and graft experiments. In particular, our system improves on previous models by preserving polarity in regeneration, over orders of magnitude in body size during cutting experiments and growth phases. Our model relies on tristability in cell density dynamics, between head, trunk, and tail. In addition, key to polarity preservation in regeneration, our system includes sensitivity of cell differentiation to gradients of wnt-related signals measured relative to the tissue surface. This process is particularly relevant in a small tissue layer close to wounds during their healing, and modeled here in a robust fashion through dynamic boundary conditions.

Informations sur la vidéo

Données de citation

  • DOI 10.24350/CIRM.V.19616703
  • Citer cette vidéo Stevens, Angela (24/02/2020). Signaling gradients in surface dynamics as basis for regeneration in flatworms. CIRM. Audiovisual resource. DOI: 10.24350/CIRM.V.19616703
  • URL https://dx.doi.org/10.24350/CIRM.V.19616703

Bibliographie

  • SCHEEL, Arnd, STEVENS, Angela, et TENBROCK, Christoph. Signaling gradients in surface dynamics as basis for planarian regeneration. arXiv preprint arXiv:1908.04253, 2019. - http://dx.doi.org/10.1101/733246

Dernières questions liées sur MathOverflow

Pour poser une question, votre compte Carmin.tv doit être connecté à mathoverflow

Poser une question sur MathOverflow




Inscrivez-vous

  • Mettez des vidéos en favori
  • Ajoutez des vidéos à regarder plus tard &
    conservez votre historique de consultation
  • Commentez avec la communauté
    scientifique
  • Recevez des notifications de mise à jour
    de vos sujets favoris
Donner son avis